The publication includes data concerning the number and structure of entities recorded in the National Official Business Register REGON and the number of entities of suspended activity as of the end of December 2021, as well as information on entities newly registered and signed off from the register in 2021. In order to illustrate changes and tendencies in the structure of regional economy, most data are compared with the analogous data from the previous year and selected information is shown to illustrate tendencies from the year 2000. Data in publication are presented according to ownership sectors, sections and divisions of the Polish Classification of Activities – PKD 2007, organizational and legal forms, the expected number of employed persons and also by kind of capital in the case of commercial companies. Data are presented for the whole voivodship as well as by subregions (NUTS 3), powiats and gminas.